Nature Communications (Sep 2022)
DNA methylation as a pharmacodynamic marker of glucocorticoid response and glioma survival
- J. K. Wiencke,
- Annette M. Molinaro,
- Gayathri Warrier,
- Terri Rice,
- Jennifer Clarke,
- Jennie W. Taylor,
- Margaret Wrensch,
- Helen Hansen,
- Lucie McCoy,
- Emily Tang,
- Stan J. Tamaki,
- Courtney M. Tamaki,
- Emily Nissen,
- Paige Bracci,
- Lucas A. Salas,
- Devin C. Koestler,
- Brock C. Christensen,
- Ze Zhang,
- Karl T. Kelsey
Affiliations
- J. K. Wiencke
- Department of Neurological Surgery, University of California San Francisco
- Annette M. Molinaro
- Department of Neurological Surgery, University of California San Francisco
- Gayathri Warrier
- Department of Neurological Surgery, University of California San Francisco
- Terri Rice
- Department of Neurological Surgery, University of California San Francisco
- Jennifer Clarke
- Department of Neurological Surgery, University of California San Francisco
- Jennie W. Taylor
- Department of Neurological Surgery, University of California San Francisco
- Margaret Wrensch
- Department of Neurological Surgery, University of California San Francisco
- Helen Hansen
- Department of Neurological Surgery, University of California San Francisco
- Lucie McCoy
- Department of Neurological Surgery, University of California San Francisco
- Emily Tang
- Department of Epidemiology and Biostatistics, University of California San Francisco
- Stan J. Tamaki
- Parnassus Flow Cytometry CoLab, University of California San Francisco
- Courtney M. Tamaki
- Parnassus Flow Cytometry CoLab, University of California San Francisco
- Emily Nissen
- Department of Biostatistics & Data Science, University of Kansas Medical Center
- Paige Bracci
- Department of Epidemiology and Biostatistics, University of California San Francisco
- Lucas A. Salas
- Department of Epidemiology, Geisel School of Medicine, Dartmouth College
- Devin C. Koestler
- Department of Biostatistics & Data Science, University of Kansas Medical Center
- Brock C. Christensen
- Department of Epidemiology, Geisel School of Medicine, Dartmouth College
- Ze Zhang
- Department of Epidemiology, Geisel School of Medicine, Dartmouth College
- Karl T. Kelsey
- Department of Epidemiology, Brown University
- DOI
- https://doi.org/10.1038/s41467-022-33215-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Glucocorticoids, such as dexamethasone, are used as anti-inflammatory and immunosuppressive drugs, however patients may exhibit resistance or side effects. Here the authors propose that a dexamethasone related neutrophil-specific DNA methylation index can be used as a marker of glucocorticoid exposure and response and as a prognostic factor in brain tumor survival.
