Ginger Extract-Loaded Sesame Oil-Based Niosomal Emulgel: Quality by Design to Ameliorate Anti-Inflammatory Activity
Marwa H. Abdallah,
Hanaa A. Elghamry,
Nasrin E. Khalifa,
Weam M. A. Khojali,
El-Sayed Khafagy,
Amr S. Abu Lila,
Hemat El-Sayed El-Horany,
Shaimaa El-Housiny
Affiliations
Marwa H. Abdallah
Department of Pharmaceutics, College of Pharmacy, University of Ha’il, Ha’il 81442, Saudi Arabia 2 Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt 3 Department of Pharmaceutics, Faculty of Pharmacy, University of Khartoum, Khartoum 11115, Sudan 4 Department of Pharmaceutical Chemistry, College of Pharmacy, University of Ha’il, Ha’il 81442, Saudi Arabia 5 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Omdurman Islamic University, Omdurman 14415, Sudan 6 Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-kharj 11942, Saudi Arabia 7 Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia 41552, Egypt 8 Department of Biochemistry, College of Medicine, University of Ha’il, Ha’il 81442, Saudi Arabia 9 Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Tanta 31511, Egypt 10 Department of Pharmaceutics and Industrial pharmacy, Faculty of Pharmacy, Modern University for Technology and Information, Cairo 4410240, Egypt
Hanaa A. Elghamry
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt
Nasrin E. Khalifa
Department of Pharmaceutics, College of Pharmacy, University of Ha’il, Ha’il 81442, Saudi Arabia 2 Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt 3 Department of Pharmaceutics, Faculty of Pharmacy, University of Khartoum, Khartoum 11115, Sudan 4 Department of Pharmaceutical Chemistry, College of Pharmacy, University of Ha’il, Ha’il 81442, Saudi Arabia 5 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Omdurman Islamic University, Omdurman 14415, Sudan 6 Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-kharj 11942, Saudi Arabia 7 Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia 41552, Egypt 8 Department of Biochemistry, College of Medicine, University of Ha’il, Ha’il 81442, Saudi Arabia 9 Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Tanta 31511, Egypt 10 Department of Pharmaceutics and Industrial pharmacy, Faculty of Pharmacy, Modern University for Technology and Information, Cairo 4410240, Egypt
Weam M. A. Khojali
Department of Pharmaceutical Chemistry, College of Pharmacy, University of Ha’il, Ha’il 81442, Saudi Arabia
El-Sayed Khafagy
Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-kharj 11942, Saudi Arabia
Amr S. Abu Lila
Department of Pharmaceutics, College of Pharmacy, University of Ha’il, Ha’il 81442, Saudi Arabia 2 Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt 3 Department of Pharmaceutics, Faculty of Pharmacy, University of Khartoum, Khartoum 11115, Sudan 4 Department of Pharmaceutical Chemistry, College of Pharmacy, University of Ha’il, Ha’il 81442, Saudi Arabia 5 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Omdurman Islamic University, Omdurman 14415, Sudan 6 Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-kharj 11942, Saudi Arabia 7 Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia 41552, Egypt 8 Department of Biochemistry, College of Medicine, University of Ha’il, Ha’il 81442, Saudi Arabia 9 Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Tanta 31511, Egypt 10 Department of Pharmaceutics and Industrial pharmacy, Faculty of Pharmacy, Modern University for Technology and Information, Cairo 4410240, Egypt
Hemat El-Sayed El-Horany
Department of Biochemistry, College of Medicine, University of Ha’il, Ha’il 81442, Saudi Arabia
Shaimaa El-Housiny
Department of Pharmaceutics and Industrial pharmacy, Faculty of Pharmacy, Modern University for Technology and Information, Cairo 4410240, Egypt
Ginger, a natural plant belonging to the Zingeberaceae family, has been reported to have reasonable anti-inflammatory effects. The current study aimed to examine ginger extract transdermal delivery by generating niosomal vesicles as a promising nano-carrier incorporated into emulgel prepared with sesame oil. Particle size, viscosity, in vitro release, and ex vivo drug penetration experiments were performed on the produced formulations (ginger extract loaded gel, ginger extract loaded emulgel, ginger extract niosomal gel, and ginger extract niosomal emulgel). Carrageenan-induced edema in rat hind paw was employed to estimate the in vivo anti-inflammatory activity. The generated ginger extract formulations showed good viscosity and particle size. The in vitro release of ginger extract from niosomal formulation surpassed other formulations. In addition, the niosomal emulgel formulation showed improved transdermal flux and increased drug permeability through rabbit skin compared to other preparations. Most importantly, carrageenan-induced rat hind paw edema test confirmed the potential anti-inflammatory efficacy of ginger extract niosomal emulgel, compared to other formulations, as manifested by a significant decrease in paw edema with a superior edema inhibition potency. Overall, our findings suggest that incorporating a niosomal formulation within sesame oil-based emulgel might represent a plausible strategy for effective transdermal delivery of anti-inflammatory drugs like ginger extract.
