Frontiers in Physiology (Nov 2015)

Adipokines, diabetes and atherosclerosis: an inflammatory association

  • Leandro Ceotto Freitas Lima,
  • Valdir de Andrade Barga,
  • Maria edo Socorro de França Silva,
  • Josiane de Campos Cruz,
  • Sérgio Henrique Sousa Santos,
  • Sérgio Henrique Sousa Santos,
  • Matheus Morais de Oliveira Monteiro,
  • Camille M Balarini,
  • Camille M Balarini

DOI
https://doi.org/10.3389/fphys.2015.00304
Journal volume & issue
Vol. 6

Abstract

Read online

Cardiovascular diseases can be considered the most important cause of death in diabetic population and diabetes can in turn increase the risk of cardiovascular events. Inflammation process is currently recognized as responsible for the development and maintenance of diverse chronic diseases, including diabetes and atherosclerosis. Considering that adipose tissue is an important source of adipokines, which may present anti and proinflammatory effects, the aim of this review is to explore the role of the main adipokines in the pathophysiology of diabetes and atherosclerosis, highlighting the therapeutic options that could arise from the manipulation of these signaling pathways both in humans and in translational models.

Keywords