Function and regulation of cGAS-STING signaling in infectious diseases

Yang Du; Yang Du; Zhiqiang Hu; Yien Luo; Helen Y. Wang; Helen Y. Wang; Xiao Yu; Xiao Yu; Rong-Fu Wang; Rong-Fu Wang

doi:10.3389/fimmu.2023.1130423

Frontiers in Immunology (Feb 2023)

Function and regulation of cGAS-STING signaling in infectious diseases

Yang Du,
Yang Du,
Zhiqiang Hu,
Yien Luo,
Helen Y. Wang,
Helen Y. Wang,
Xiao Yu,
Xiao Yu,
Rong-Fu Wang,
Rong-Fu Wang

Affiliations

Yang Du: Department of Medicine, and Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States
Yang Du: Research Center of Medical Sciences, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China
Zhiqiang Hu: Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China
Yien Luo: Department of Neurology, Guangdong Neuroscience Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China
Helen Y. Wang: Department of Medicine, and Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States
Helen Y. Wang: Department of Pediatrics, Children’s Hospital, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States
Xiao Yu: Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China
Xiao Yu: Guangdong Provincial Key Lab of Single Cell Technology and Application, Southern Medical University, Guangzhou, Guangdong, China
Rong-Fu Wang: Department of Medicine, and Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States
Rong-Fu Wang: Department of Pediatrics, Children’s Hospital, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States

DOI: https://doi.org/10.3389/fimmu.2023.1130423
Journal volume & issue: Vol. 14

Abstract

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The efficacious detection of pathogens and prompt induction of innate immune signaling serve as a crucial component of immune defense against infectious pathogens. Over the past decade, DNA-sensing receptor cyclic GMP-AMP synthase (cGAS) and its downstream signaling adaptor stimulator of interferon genes (STING) have emerged as key mediators of type I interferon (IFN) and nuclear factor-κB (NF-κB) responses in health and infection diseases. Moreover, both cGAS-STING pathway and pathogens have developed delicate strategies to resist each other for their survival. The mechanistic and functional comprehension of the interplay between cGAS-STING pathway and pathogens is opening the way for the development and application of pharmacological agonists and antagonists in the treatment of infectious diseases. Here, we briefly review the current knowledge of DNA sensing through the cGAS-STING pathway, and emphatically highlight the potent undertaking of cGAS-STING signaling pathway in the host against infectious pathogenic organisms.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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Abstract

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