Development of a Web Application for the Detection of Coronary Artery Calcium from Computed Tomography

Abstract

Coronary atherosclerosis is the most common form of cardiovascular diseases, which represent the leading global cause of mortality in the adult population. The amount of coronary artery calcium (CAC) is a robust predictor of this disease that can be measured using the medical workstations of computed tomography (CT) equipment or specialized tools included in commercial software for DICOM viewers, which is not available for all operating systems. This manuscript presents a web application that semiautomatically quantifies the amount of coronary artery calcium (CAC) on the basis of the coronary calcium score (CS) using the Agatston technique through digital image processing. To verify the correct functioning of this web application, 30 CTCSs were analyzed by a cardiologist and compared to those of commercial software (OsiriX DICOM Viewer).All the scans were correctly classified according to the cardiovascular event risk group, with an average error in the calculation of CS of 1.9% and a Pearson correlation coefficient r = 0.9997, with potential clinical application.

Keywords

• Agatston score
• computed tomography
• coronary artery calcium
• image processing
• web application