Nature Communications (Jul 2021)
Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity
- Linh T. Bui,
- Nichelle I. Winters,
- Mei-I Chung,
- Chitra Joseph,
- Austin J. Gutierrez,
- Arun C. Habermann,
- Taylor S. Adams,
- Jonas C. Schupp,
- Sergio Poli,
- Lance M. Peter,
- Chase J. Taylor,
- Jessica B. Blackburn,
- Bradley W. Richmond,
- Andrew G. Nicholson,
- Doris Rassl,
- William A. Wallace,
- Ivan O. Rosas,
- R. Gisli Jenkins,
- Naftali Kaminski,
- Jonathan A. Kropski,
- Nicholas E. Banovich,
- Human Cell Atlas Lung Biological Network
Affiliations
- Linh T. Bui
- Translational Genomics Research Institute
- Nichelle I. Winters
- Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center
- Mei-I Chung
- Translational Genomics Research Institute
- Chitra Joseph
- Respiratory Medicine NIHR Biomedical Research Centre, University of Nottingham
- Austin J. Gutierrez
- Translational Genomics Research Institute
- Arun C. Habermann
- Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center
- Taylor S. Adams
- Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine
- Jonas C. Schupp
- Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine
- Sergio Poli
- Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Lance M. Peter
- Translational Genomics Research Institute
- Chase J. Taylor
- Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center
- Jessica B. Blackburn
- Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center
- Bradley W. Richmond
- Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center
- Andrew G. Nicholson
- National Heart and Lung Institute, Imperial College
- Doris Rassl
- Pathology Research, Royal Papworth Hospital NHS Foundation Trust
- William A. Wallace
- Department of Pathology, Royal Infirmary of Edinburgh
- Ivan O. Rosas
- Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Baylor College of Medicine
- R. Gisli Jenkins
- Respiratory Medicine NIHR Biomedical Research Centre, University of Nottingham
- Naftali Kaminski
- Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine
- Jonathan A. Kropski
- Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center
- Nicholas E. Banovich
- Translational Genomics Research Institute
- Human Cell Atlas Lung Biological Network
- DOI
- https://doi.org/10.1038/s41467-021-24467-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Patients with chronic lung disease (CLD) have an increased risk for severe coronavirus disease-19 and poor outcomes. Here the authors compare the transcriptomes of single cells isolated from healthy and CLD lungs to identify molecular characteristics of lung cells that may account for worse COVID-19 outcomes in these patients.
