Nature Communications (Jun 2020)

Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons

  • M. Catarina Silva,
  • Ghata A. Nandi,
  • Sharon Tentarelli,
  • Ian K. Gurrell,
  • Tanguy Jamier,
  • Diane Lucente,
  • Bradford C. Dickerson,
  • Dean G. Brown,
  • Nicholas J. Brandon,
  • Stephen J. Haggarty

DOI
https://doi.org/10.1038/s41467-020-16984-1
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 18

Abstract

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Disruption of autophagy function in cellular and animal models of tauopathy increases tau aggregation. Here, the authors describe a small-molecule screen to identify compounds that promote autophagy clearance of tau and rescue disease-relevant phenotypes in tauopathy patient-derived neurons.