Membrane pools of phosphatidylinositol-4-phosphate regulate KCNQ1/KCNE1 membrane expression

Chen Braun; Xiaorong Xu Parks; Haani Qudsi; Coeli M. B. Lopes

doi:10.1038/s42003-021-02909-1

Communications Biology (Dec 2021)

Membrane pools of phosphatidylinositol-4-phosphate regulate KCNQ1/KCNE1 membrane expression

Chen Braun,
Xiaorong Xu Parks,
Haani Qudsi,
Coeli M. B. Lopes

Affiliations

Chen Braun: Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry
Xiaorong Xu Parks: Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry
Haani Qudsi: Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry
Coeli M. B. Lopes: Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry

DOI: https://doi.org/10.1038/s42003-021-02909-1
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 10

Abstract

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Braun et al. investigate the effects of PI 4-kinases and their lipid product, PI4P, in KCNQ channel function and sub-cellular localization. These results suggest a possible harmful effect of PI4K inhibition on cardiac electrophysiology and suggest the distal C-terminus of the channel is critical for PI4P regulation of the KCNQ1/KCNE1 channel.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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