Heterogenous mutation spectrum and deregulated cellular pathways in aberrant plasma cells underline molecular pathology of light-chain amyloidosis

• Zuzana Chyra,
• Tereza Sevcikova,
• Petr Vojta,
• Janka Puterova,
• Lucie Brozova,
• Katerina Growkova,
• Jana Filipova,
• Martina Zatopkova,
• Sebastian Grosicki,
• Agnieszka Barchnicka,
• Wieslaw Wiktor Jedrzejczak,
• Anna Waszczuk-Gajda,
• Alexandra Jungova,
• Aneta Mikulasova,
• Marian Hajduch,
• Martin Mokrejs,
• Ludek Pour,
• Martin Stork,
• Lubica Harvanova,
• Martin Mistrik,
• Gabor Mikala,
• Pawel Robak,
• Anna Czyz,
• Jakub Debski,
• Lidia Usnarska-Zubkiewicz,
• Artur Jurczyszyn,
• Lukas Stejskal,
• Gareth Morgan,
• Fedor Kryukov,
• Eva Budinska,
• Michal Simicek,
• Tomas Jelinek,
• Matous Hrdinka,
• Roman Hajek

Affiliations

Zuzana Chyra

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA;

Tereza Sevcikova

Dpt. of Clinical studies, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic;

Petr Vojta

Institute of Molecular and Translational Medicine, Palacky University, Olomouc, Czech Republic;

Janka Puterova

Brno University of Technology, Centre of Excellence IT4Innovations, Brno, Czech Republic;

Lucie Brozova

Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic;

Katerina Growkova

Dpt. of Clinical studies, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic;

Jana Filipova

Department of Biology and Ecology, Faculty of Science, University of Ostrava, Czech Republic;

Martina Zatopkova

Dpt. of Clinical studies, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic;

Sebastian Grosicki

Dept. of Hematology and Cancer Prevention, Medical University of Silesia in Katowice, Poland;

Agnieszka Barchnicka

Dept. of Hematology and Cancer Prevention, Medical University of Silesia in Katowice, Poland;

Wieslaw Wiktor Jedrzejczak

Department of Haematology, Oncology and Internal Diseases, Medical University of Warsaw, Poland;

Anna Waszczuk-Gajda

Department of Haematology, Oncology and Internal Diseases, Medical University of Warsaw, Poland;

Alexandra Jungova

Charles University Hospital Pilsen, Czech Republic;

Aneta Mikulasova

Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom;

Marian Hajduch

Institute of Molecular and Translational Medicine, Palacky University, Olomouc, Czech Republic;

Martin Mokrejs

IT4Innovations, VSB, Technical University of Ostrava, Ostrava, Czech Republic;

Ludek Pour

Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Czech Republic;

Martin Stork

Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Czech Republic;

Lubica Harvanova

Department of Haematology and Transfusiology, University Hospital Bratislava, Slovakia;

Martin Mistrik

Department of Haematology and Transfusiology, University Hospital Bratislava, Slovakia;

Gabor Mikala

Dept. of Haematology ‎& Stem Cell Transplantation, South Pest Central Hospital, Budapest, Hungary;

Pawel Robak

Department of Haematology, Medical University of Lodz, Copernicus Memorial Hospital, Łódź, Poland;

Anna Czyz

Dept. and Clinic of Haematology, Blood Neoplasms, Wroclaw Medical University, Poland;

Jakub Debski

Dept. and Clinic of Haematology, Blood Neoplasms, Wroclaw Medical University, Poland;

Lidia Usnarska-Zubkiewicz

Dept. and Clinic of Haematology, Blood Neoplasms, Wroclaw Medical University, Poland;

Artur Jurczyszyn

Jagiellonian University Medical College, Cracow, Poland;

Lukas Stejskal

Silesian Hospital Opava, Opava, Czech Republic;

Gareth Morgan

Dpt. of Medicine, Multiple Myeloma Research Perlmutter Cancer Center, NYU School of Medicine, USA;

Fedor Kryukov

Department of Haematooncology, University Hospital Ostrava, Ostrava, Czech Republic;

Eva Budinska

RECETOX, Faculty of Science, Masaryk university in Brno, Brno, Czech Republic

Michal Simicek

Dpt. of Clinical studies, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic;

Tomas Jelinek

Department of Haematooncology, University Hospital Ostrava, Ostrava, Czech Republic;

Matous Hrdinka

Dpt. of Clinical studies, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic;

Roman Hajek

Department of Haematooncology, University Hospital Ostrava, Ostrava, Czech Republic;