Nature Communications (Oct 2019)

Gingival solitary chemosensory cells are immune sentinels for periodontitis

  • Xin Zheng,
  • Marco Tizzano,
  • Kevin Redding,
  • Jinzhi He,
  • Xian Peng,
  • Peihua Jiang,
  • Xin Xu,
  • Xuedong Zhou,
  • Robert F. Margolskee

DOI
https://doi.org/10.1038/s41467-019-12505-x
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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Solitary chemosensory cells (SCCs) expressing taste receptors reside in mucosal epithelia including the gingiva. Here the authors show that ablation of taste-sensing by SSCs leads to outgrowth of pathogenic oral bacteria and periodontitis, whereas bitter taste receptor stimulation promotes antimicrobial peptide production and ameliorates periodontitis.