Journal of Diabetes (Feb 2022)

基于多中心前瞻性真实世界数据的基础胰岛素和预混合胰岛素对2型糖尿病患者血糖控制的影响研究

  • Ying Peng,
  • Peihong Xu,
  • Juan Shi,
  • Yifei Zhang,
  • Shujie Wang,
  • Qidong Zheng,
  • Yufan Wang,
  • Tingyu Ke,
  • Li Li,
  • Dong Zhao,
  • Yuancheng Dai,
  • Qijuan Dong,
  • Bangqun Ji,
  • Fengmei Xu,
  • Weiqiong Gu,
  • Weiqing Wang

DOI
https://doi.org/10.1111/1753-0407.13245
Journal volume & issue
Vol. 14, no. 2
pp. 134 – 143

Abstract

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Abstract Background To investigate the different efficacies of glycemic control between basal and premixed insulin in participants with type 2 diabetes (T2DM) when non‐insulin medications fail to reach treatment targets. Methods This was a prospective, large‐scale, real‐world study at 10 diabetes centers in China. Between June 2017 and June 2021, we enrolled 1104 T2DM participants initiated with either once‐daily basal insulin or twice‐daily premixed insulin when the glycosylated hemoglobin (HbA1c) control target was not met after at least two non‐insulin agents were administered. A Cox proportional hazards regression model adjusting for multiple influencing factors was performed to compare the different effects of basal and premixed insulin on reaching the HbA1c control target. Results At baseline, basal insulin (57.3%) was prescribed more frequently than premixed insulin (42.7%). Patients with a higher body mass index (BMI) or higher HbA1c levels were more likely to receive premixed insulin than basal insulin (both p < 0.001). After a median follow‐up of 12.0 months, compared to those with premixed insulin, the hazard ratio for reaching the HbA1c target to those with basal insulin was 1.10 (95% CI, 0.92‐1.31; p = 0.29) after adjustment, and less weight gain was observed in those with basal insulin than with premixed insulin (percentage change of BMI from baseline −0.37[5.50]% vs 3.40[6.73]%, p < 0.0001). Conclusions In this real‐world study, once‐daily basal insulin was more frequently prescribed and had similar glycemic control effects but less weight gain compared with twice‐daily premixed insulin when used as initiation therapy for those in whom glycemic control with non‐insulin medications failed.

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