Type of course of schizophrenia and polymorphisms of neuronal protein kinase genes on the model of PIP5K2A, GSK3B and AKT1

Abstract

The role of protein kinases in schizophrenia is being actively studied. However, the effect of protein kinase gene polymorphisms on the clinical manifestations of the disease has been little studied. We examined 384 patients diagnosed with schizophrenia in accordance with ICD-10 (F20) (269 patients with a continuous course of schizophrenia; 115 patients with an episodic course of the disease). Genotyping of polymorphisms PIP5K2A (rs10828317, rs8341, rs746203), GSK3B (rs334558), AKT1 (rs3730358, rs1130214) was carried out by real-time PCR method. An association of rs8341 PIP5K2A with the type of course of schizophrenia was revealed. The CT genotype was associated with a continuous type of schizophrenia, the TT genotype with an episodic one. Disorders of the phosphoinositide pathway may be a possible cause of the transition to a more severe continuous course of schizophrenia.

Keywords

• schizophrenia, pip5k2a, gsk3b, akt1, gene polymorphism