Challenges in the Monitoring of Therapeutic Plasma Exchange during Acute Heparin-Induced Thrombocytopenia in Adults under ECMO

Nicolas Gendron; Candice Cavalie; Elie Kantor; Sophie Provenchère; Romain Sonneville; Vasiliki Gkalea; Marie-Charlotte Bourrienne; Dorothée Faille; Nadine Ajzenberg

doi:10.1055/a-2277-4404

TH Open (Jan 2024)

Challenges in the Monitoring of Therapeutic Plasma Exchange during Acute Heparin-Induced Thrombocytopenia in Adults under ECMO

Nicolas Gendron,
Candice Cavalie,
Elie Kantor,
Sophie Provenchère,
Romain Sonneville,
Vasiliki Gkalea,
Marie-Charlotte Bourrienne,
Dorothée Faille,
Nadine Ajzenberg

Affiliations

Nicolas Gendron: ORCiD; Innovative Therapies in Haemostasis, Paris Cité University, INSERM, Paris, France
Candice Cavalie: Université de Paris, INSERM U1148, LVTS, F-75018, Paris, France
Elie Kantor: Anesthesiology Department and Surgical Intensive Care, DMU PARABOL, AH-HP, Bichat–Claude Bernard Hospital, Paris, France
Sophie Provenchère: Anesthesiology Department and Surgical Intensive Care, DMU PARABOL, AH-HP, Bichat–Claude Bernard Hospital, Paris, France
Romain Sonneville: Laboratory of Vascular Translational Science, Paris Cité University, INSERM, Paris, France
Vasiliki Gkalea: Laboratoire d’Hématologie Biologique, AP-HP, Hôpital Bichat, F-75018, Paris, France
Marie-Charlotte Bourrienne: ORCiD; Université de Paris, INSERM U1148, LVTS, F-75018, Paris, France
Dorothée Faille: Université de Paris, INSERM U1148, LVTS, F-75018, Paris, France
Nadine Ajzenberg: Université de Paris, INSERM U1148, LVTS, F-75018, Paris, France

DOI: https://doi.org/10.1055/a-2277-4404
Journal volume & issue: Vol. 08, no. 01
pp. e141 – e145

Abstract

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Therapeutic plasma exchange (TPE) has been proposed to remove heparin-induced thrombocytopenia (HIT) antibodies before planned thoracic surgery in patients with acute HIT and to allow brief re-exposure to heparin during surgery. In patients on extracorporeal membrane oxygenation (ECMO), simultaneous administration of TPE and alternative nonheparin anticoagulant therapies is challenging.

Published in TH Open

ISSN: 2512-9465 (Online)
Publisher: Georg Thieme Verlag KG
Country of publisher: Germany
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://doi.org/10.1055/s-00033990

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