Synthesis of [(4-Chloro-5H-1,2,3-dithiazol-5-ylidene)amino]azines

Abstract

The reactions of 2-, 3- and 4-aminopyridines with 4,5-dichloro-1,2,3-dithiazol-ium chloride (Appel salt) 4 to give N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)pyridin-X-amines 1a (X = 2), 1g (X = 3) and 1k (X = 4) were optimized with respect to base, temperature and reaction time. Based on these conditions a total of thirteen [(dithiazol-ylidene)amino]azines 1a-m were prepared and fully characterized.

Keywords

• heterocycle
• Appel salt
• 1,2,3-dithiazoles
• condensation
• azine