Einstein (São Paulo) (Nov 2024)

The role of microRNAs in non-invasive diagnosis of bladder cancer: a systematic review

  • Pedro Ivo de Sousa Neto,
  • Vicktor Bruno Pereira Pinto,
  • Elaine dos Santos Piancó,
  • Malene Lima Gomes,
  • Sally Cristina Moutinho Monteiro,
  • Flávia Castello Branco Vidal,
  • Maria do Desterro Soares Brandão Nascimento,
  • Jaqueline Diniz Pinho,
  • José de Ribamar Rodrigues Calixto,
  • Marcelo Souza de Andrade

DOI
https://doi.org/10.31744/einstein_journal/2024rw0611
Journal volume & issue
Vol. 22

Abstract

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ABSTRACT Objective: MicroRNAs are small non-coding RNAs that are abundantly expressed in various biofluids, making them promising candidates for cancer biomarkers. This review aims to present current evidence on the use of miRNA as biomarkers for the non-invasive diagnosis of bladder cancer. Methods: A systematic literature review, using the Medline database, was performed in July 2022 according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. All articles were required to satisfy the risk-of-bias assessment using the Joanna Briggs Institute Critical Assessment Tools. Data were collected based on miRNA expression, sample type, expression profiles, and accuracy. Results: The initial search retrieved 437 studies, 21 of which were included in the final analysis. Most studies on miRNA expression in human fluids used urine samples for analysis. Conclusion: There is a trend to cluster the expressed miRNAs to build diagnostic panels or use them in association with other diagnostic methods to achieve reasonable accuracy. Prospero database registration: (https://www.crd.york.ac.uk/prospero/) under ID CRD42022351686.

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