Infection and Drug Resistance (Nov 2021)
SARS-CoV-2-Associated Cerebrovascular Disease Amid the COVID-19 Pandemic: A Systematic Review
Abstract
Tao Yu,1,* Hongquan Wang,2,* Shuhan Zheng,1 Liang Huo1 1Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, 110004, Liaoning, People’s Republic of China; 2Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin, 300060, People’s Republic of China*These authors contributed equally to this workCorrespondence: Liang HuoDepartment of Pediatrics, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, Liaoning, 110004, People’s Republic of ChinaEmail [email protected]: Cerebrovascular diseases associated with SARS-CoV-2 are being increasingly reported in the literature as the coronavirus disease 2019 (COVID-19) pandemic continues. However, a case-based retrospective analysis of the literature about SARS-CoV-2-cerebrovascular disease (SCVD) is not yet well established. Thus, we reviewed the literature on SCVD covering a comprehensive range of topics spanning the clinical features, mechanism, treatment, and outcomes of patients with SCVD.Methods: We searched PubMed® and included single-case reports and case series with full text in English that reported original data of patients with CVD and a confirmed recent SARS-CoV-2 infection. Clinical data were extracted.Results: We included all 51 articles indexed in PubMed® that were published between January 1, 2020, and June 20, 2020. The selected studies reported a total of 167 cerebrovascular events including ischemic stroke, cerebral hemorrhage, subarachnoid hemorrhage, and cerebral venous thrombosis in patients with confirmed COVID-19. The detailed demographic and clinical characteristics of patients with CVD are summarized.Conclusion: This summary of patient characteristics may help clinicians better anticipate SCVD outcomes and complications in their COVID-19 patients.Keywords: COVID-19, cerebrovascular disease, stroke, cerebral hemorrhage, cerebral venous thrombosis
