Neurotrophic Factors as Markers of Stroke Recovery: a Review

Abstract

INTRODUCTION. A review of studies on the role of neurotrophic factors: BDNF, NGF, BDNF, NGF, NT-3, NT-4/5, IGF-1 and other biomarkers, in predicting and enhancing ischemic stroke (IS) recovery is presented. AIM. To analyze recent data on the role of neurotrophic factors in recovery processes post-stroke rehabilitation. MAIN CONTENT OF THE REVIEW. High-level evidence-based works (randomized controlled trials, meta-analyses, systematic reviews) found in PubMed and Cochrane Library databases are included, ClinicalTrials.gov. for 2013–2025. The data on the importance of neurotrophic factors (NTF) in various periods of IS, as well as the effects of physical activity, genetic polymorphisms, and new therapeutic approaches aimed at increasing NTF levels are considered. NTFs have significant potential for predicting recovery outcomes and optimizing post-stroke rehabilitation. CONCLUSION. Combining physical rehabilitation with pharmacological strategies targeting NTF mechanisms could lead to innovative therapies to improve stroke survivors’ quality of life.

Keywords

• stroke
• medical rehabilitation
• functional outcome
• neurotrophic factors
• bdnf
• risk factors