Hypolipidemic and Antioxidant Effects of <i>Guishe</i> Extract from <i>Agave lechuguilla,</i> a Mexican Plant with Biotechnological Potential, on Streptozotocin-Induced Diabetic Male Rats
Edgar R. Esquivel-Gutiérrez,
Salvador Manzo-Avalos,
Donovan J. Peña-Montes,
Alfredo Saavedra-Molina,
Zoé P. Morreeuw,
Ana G. Reyes
Affiliations
Edgar R. Esquivel-Gutiérrez
Centro de Investigaciones Biológicas del Noroeste S.C., Av. Instituto Politécnico Nacional 195, Col. Playa Palo de Santa Rita Sur, La Paz C.P. 23096, Baja California Sur, Mexico
Salvador Manzo-Avalos
Instituto de Investigaciones, Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia C.P. 58030, Michoacan, Mexico
Donovan J. Peña-Montes
Instituto de Investigaciones, Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia C.P. 58030, Michoacan, Mexico
Alfredo Saavedra-Molina
Instituto de Investigaciones, Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia C.P. 58030, Michoacan, Mexico
Zoé P. Morreeuw
Centro de Investigaciones Biológicas del Noroeste S.C., Av. Instituto Politécnico Nacional 195, Col. Playa Palo de Santa Rita Sur, La Paz C.P. 23096, Baja California Sur, Mexico
Ana G. Reyes
CONACYT—Centro de Investigaciones Biológicas del Noroeste S.C., Av. Instituto Politécnico Nacional 195, Col. Playa Palo de Santa Rita Sur, La Paz C.P. 23096, Baja California Sur, Mexico
In the present study, we used a by-product from Agave lechuguilla (guishe) to test its antidiabetic effect, hypolipidemic activity, and capacity to mitigate the oxidative stress in kidney mitochondria from streptozotocin-induced diabetic rats. Orally, a crude aqueous extract from lyophilized guishe was administered over 5 weeks at different doses. Blood glucose and body weight were monitored. Also, blood chemistry, bilirubin, and alanine aminotransferase were assayed. Furthermore, the activity of catalase, thiobarbituric acid reactive species, mitochondrial superoxide dismutase, glutathione and glutathione peroxidase were determined in isolated kidney mitochondria. Our results show that guishe extracts have no antidiabetic properties at any dose. Nevertheless, it was able to diminish serum triglyceride levels and regulate the oxidative stress observed in isolated kidney mitochondria. These observations indicate that the aqueous extract from guishe can be used to treat abnormalities in serum lipids, as a hypolipidemic, and mitigate the oxidative stress, as an antioxidant, occurring during diabetes.