Construction of Microparticles Based on Resorbable Polymers Bioplastotan Using Spray Drying Method

Abstract

The possibility of using the spray drying method for the construction of poly-3-hydroxybutyrate (P3HB) based microparticles was studied. The dependence of characteristics of microparticles (yield, average diameter, zeta-potential) from processing parameters (temperature at the inlet of the system, the feed rate of polymer solution and concentration of the polymer solution) was found. It is shown that zeta potential of microparticles was influenced by concentration of the polymer solution, and the average diameter was determined by temperature of the inlet. Also, conditions of obtaining P3HB microparticles were optimized to minimize polymer loss (approximately 10 %)

Keywords

• drug delivery systems
• polyhydroxyalkanoates
• spray drying
• microparticles
• D-optimal design