Faculty of Industrial Chemistry and Environmental Engineering, Politehnica University of Timişoara, 2 Piata Victoriei, 300006 Timisoara, Romania
Corneliu Mircea Davidescu
Renewable Energy Research Institute-ICER, University Politehnica of Timisoara, 138 Gavril Musicescu Street, 300501 Timisoara, Romania
Nicoleta Sorina Nemeş
Renewable Energy Research Institute-ICER, University Politehnica of Timisoara, 138 Gavril Musicescu Street, 300501 Timisoara, Romania
Adina Negrea
Faculty of Industrial Chemistry and Environmental Engineering, Politehnica University of Timişoara, 2 Piata Victoriei, 300006 Timisoara, Romania
Mihaela Ciopec
Faculty of Industrial Chemistry and Environmental Engineering, Politehnica University of Timişoara, 2 Piata Victoriei, 300006 Timisoara, Romania
Narcis Duteanu
Faculty of Industrial Chemistry and Environmental Engineering, Politehnica University of Timişoara, 2 Piata Victoriei, 300006 Timisoara, Romania
Petru Negrea
Faculty of Industrial Chemistry and Environmental Engineering, Politehnica University of Timişoara, 2 Piata Victoriei, 300006 Timisoara, Romania
Daniel Duda-Seiman
Department of Cardiology, Victor Babes University of Medicine and Pharmacy Timişoara, 2 Piata Eftimie Murgu, 300041 Timisoara, Romania
Delia Muntean
Multidisciplinary Research Center on Antimicrobial Resistance, Department of Microbiology, Victor Babes University of Medicine and Pharmacy Timişoara, 2 Eftimie Murgu Square, 300041 Timisoara, Romania
Considering the challenge created by the development of bacterial and fungal strains resistant to multiple therapeutic variants, new molecules and materials with specific properties against these microorganisms can be synthesized, like those synthesized from biopolymers such as chitosan with improved antimicrobial activities. Antimicrobial activities of seven obtained materials were tested on four reference strains belonging to American Type Culture Collection. The best antimicrobial activity was obtained by functionalization by impregnation of chitosan with quaternary ammonium salts, followed by that obtained by functionalization of chitosan with phosphonium. The lowest antibacterial and antifungal effects were expressed by Ch-THIO and Ch-MBT, but new materials obtained with these extractants may be precursors with a significant role in the direct control of active molecules, such as cell growth factors or cell signaling molecules.
