氧化脂质在脑血管病中的研究进展 Advances of Oxylipins in Cerebrovascular Diseases

Abstract

氧化脂质是由多不饱和脂肪酸氧化产生的生物活性脂质。近年来，越来越多的研究证明氧化脂质可通过炎症反应、氧化应激、细胞凋亡、血管稳态等多种机制影响脑血管病的发生发展。另外，基于代谢组学的临床研究发现氧化脂质在脑血管病不同表型或预后患者中的水平存在差异。研究氧化脂质在脑血管病中的作用有助于为脑血管病的诊断、治疗及预防提供新思路、新方法。 Abstract: Oxylipins are bioactive lipids formed by the oxidation of polyunsaturated fatty acids. In recent years, an increasing number of studies have demonstrated that oxylipins can influence the occurrence and development of cerebrovascular diseases through diverse mechanisms such as inflammation response, oxidative stress, apoptosis, and vascular homeostasis. Besides, clinical studies based on metabolomics have found that there are differences in the levels of oxylipins in patients with different phenotypes or prognosis of cerebrovascular diseases. Studying the roles of oxylipins in cerebrovascular diseases can provide new insights and approaches for the diagnosis, treatment and prevention of cerebrovascular diseases.

Keywords

• 氧化脂质
• 代谢组学
• 生物标志物
• 脑血管病
• oxylipins
• metabolomics
• biomarker
• cerebrovascular disease