The endosomal Q-SNARE, Syntaxin 7, defines a rapidly replenishing synaptic vesicle recycling pool in hippocampal neurons

Abstract

Yasunori Mori et al. find that a subset of neurotransmitter-bearing synaptic vesicles are marked for release by the endosomal Q-SNARE protein Stx7. They show that Stx7 function is necessary for the rapid replenishment of synaptic vesicles that is needed to sustain synaptic transmission during high-frequency stimulation.