Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: A systematic review and meta-analysis
Adam J. Causer,
Janis K. Shute,
Michael H. Cummings,
Anthony I. Shepherd,
Mathieu Gruet,
Joseph T. Costello,
Stephen Bailey,
Martin Lindley,
Clare Pearson,
Gary Connett,
Mark I. Allenby,
Mary P. Carroll,
Thomas Daniels,
Zoe L. Saynor
Affiliations
Adam J. Causer
School of Sport, Health and Exercise Science, Faculty of Science and Health, University of Portsmouth, Portsmouth, UK; Cystic Fibrosis Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK
Janis K. Shute
School of Pharmacy and Biomedical Sciences, Faculty of Science and Health, University of Portsmouth, Portsmouth, UK
Michael H. Cummings
Department of Diabetes and Endocrinology, Queen Alexandra Hospital, Portsmouth, UK
Anthony I. Shepherd
School of Sport, Health and Exercise Science, Faculty of Science and Health, University of Portsmouth, Portsmouth, UK
Mathieu Gruet
Laboratory of Impact of Physical Activity on Health (IAPS), UR n°201723207F, University of Toulon, France
Joseph T. Costello
School of Sport, Health and Exercise Science, Faculty of Science and Health, University of Portsmouth, Portsmouth, UK
Stephen Bailey
School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK
Martin Lindley
School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK
Clare Pearson
Cystic Fibrosis Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK
Gary Connett
National Institute for Health Research, Southampton Biomedical Research Centre, Southampton Children's Hospital, Southampton, UK
Mark I. Allenby
Cystic Fibrosis Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK
Mary P. Carroll
Cystic Fibrosis Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK
Thomas Daniels
Cystic Fibrosis Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK
Zoe L. Saynor
School of Sport, Health and Exercise Science, Faculty of Science and Health, University of Portsmouth, Portsmouth, UK; Cystic Fibrosis Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Corresponding author. School of Sport, Health and Exercise Science, Faculty of Science and Health, University of Portsmouth, Portsmouth, Hampshire, PO1 2ER, UK.
Introduction: Oxidative stress may play an important role in the pathophysiology of cystic fibrosis (CF). This review aimed to quantify CF-related redox imbalances. Methods: Systematic searches of the Medline, CINAHL, CENTRAL and PsycINFO databases were conducted. Mean content of blood biomarkers from people with clinically-stable CF and non-CF controls were used to calculate the standardized mean difference (SMD) and 95% confidence intervals (95% CI). Results: Forty-nine studies were eligible for this review including a total of 1792 people with CF and 1675 controls. Meta-analysis revealed that protein carbonyls (SMD: 1.13, 95% CI: 0.48 to 1.77), total F2-isoprostane 8-iso-prostaglandin F2α (SMD: 0.64, 95% CI: 0.23 to 1.05) and malondialdehyde (SMD: 1.34, 95% CI: 0.30 to 2.39) were significantly higher, and vitamins A (SMD: −0.66, 95% CI -1.14 to −0.17) and E (SMD: −0.74, 95% CI: −1.28 to −0.20), β-carotene (SMD: −1.80, 95% CI: −2.92 to −0.67), lutein (SMD: −1.52, 95% CI: −1.83 to −1.20) and albumin (SMD: −0.98, 95% CI: −1.68 to −0.27) were significantly lower in the plasma or serum of people with CF versus controls. Conclusions: This systematic review and meta-analysis found good evidence for reduced antioxidant capacity and elevated oxidative stress in people with clinically-stable CF.
