A toxin-antidote CRISPR gene drive system for regional population modification

Jackson Champer; Esther Lee; Emily Yang; Chen Liu; Andrew G. Clark; Philipp W. Messer

doi:10.1038/s41467-020-14960-3

Nature Communications (Feb 2020)

A toxin-antidote CRISPR gene drive system for regional population modification

Jackson Champer,
Esther Lee,
Emily Yang,
Chen Liu,
Andrew G. Clark,
Philipp W. Messer

Affiliations

Jackson Champer: Department of Computational Biology, Cornell University
Esther Lee: Department of Computational Biology, Cornell University
Emily Yang: Department of Computational Biology, Cornell University
Chen Liu: Department of Computational Biology, Cornell University
Andrew G. Clark: Department of Computational Biology, Cornell University
Philipp W. Messer: Department of Computational Biology, Cornell University

DOI: https://doi.org/10.1038/s41467-020-14960-3
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 10

Abstract

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CRISPR homing gene drives are highly invasive and can fail due to the rapid evolution of resistance. Here the authors present TARE drive, inspired by naturally occurring selfish genetic elements, which is less vulnerable to resistance and can potentially be confined to a target population.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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