Nature Communications (Jan 2018)

The evolution of substrate discrimination in macrolide antibiotic resistance enzymes

  • Andrew C. Pawlowski,
  • Peter J. Stogios,
  • Kalinka Koteva,
  • Tatiana Skarina,
  • Elena Evdokimova,
  • Alexei Savchenko,
  • Gerard D. Wright

DOI
https://doi.org/10.1038/s41467-017-02680-0
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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New antibiotics with reduced potential for resistance are urgently needed. Here, the authors use a multidisciplinary approach to characterize substrate discrimination in macrolide resistance kinases and present a strategy for the prediction of mutations that expand the substrate range of antibiotic-inactivating enzymes.