Going viral? Linking the etiology of human prostate cancer to the PCA3 long noncoding RNA and oncogenic viruses

Andre A Teixeira; Serena Marchiò; Emmanuel Dias‐Neto; Diana N Nunes; Israel T da Silva; Bryce Chackerian; Marc Barry; Richard C Lauer; Ricardo J Giordano; Richard L Sidman; Cosette M Wheeler; Webster K Cavenee; Renata Pasqualini; Wadih Arap

doi:10.15252/emmm.201708072

EMBO Molecular Medicine (Jul 2017)

Going viral? Linking the etiology of human prostate cancer to the PCA3 long noncoding RNA and oncogenic viruses

Andre A Teixeira,
Serena Marchiò,
Emmanuel Dias‐Neto,
Diana N Nunes,
Israel T da Silva,
Bryce Chackerian,
Marc Barry,
Richard C Lauer,
Ricardo J Giordano,
Richard L Sidman,
Cosette M Wheeler,
Webster K Cavenee,
Renata Pasqualini,
Wadih Arap

Affiliations

Andre A Teixeira: University of New Mexico Comprehensive Cancer Center
Serena Marchiò: University of New Mexico Comprehensive Cancer Center
Emmanuel Dias‐Neto: Laboratory of Medical Genomics, A.C.Camargo Cancer Center
Diana N Nunes: Laboratory of Medical Genomics, A.C.Camargo Cancer Center
Israel T da Silva: Laboratory of Computational Biology, A.C.Camargo Cancer Center
Bryce Chackerian: Department of Molecular Genetics and Microbiology, University of New Mexico
Marc Barry: University of New Mexico Comprehensive Cancer Center
Richard C Lauer: University of New Mexico Comprehensive Cancer Center
Ricardo J Giordano: Department of Biochemistry, Chemistry Institute, University of São Paulo
Richard L Sidman: Department of Neurology, Harvard Medical School
Cosette M Wheeler: University of New Mexico Comprehensive Cancer Center
Webster K Cavenee: Ludwig Institute for Cancer Research, University of California‐San Diego
Renata Pasqualini: University of New Mexico Comprehensive Cancer Center
Wadih Arap: University of New Mexico Comprehensive Cancer Center

DOI: https://doi.org/10.15252/emmm.201708072
Journal volume & issue: Vol. 9, no. 10
pp. 1327 – 1330

Abstract

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Graphical Abstract The hypothesis is discussed that prostate cancer marker lncRNA PCA3 was introduced into the human genome by an oncogenic virus, and that viral infection‐related mechanisms might underlie its overexpression and prostate cancer initiation and/or progression.

Published in EMBO Molecular Medicine

ISSN: 1757-4676 (Print); 1757-4684 (Online)
Publisher: Springer Nature
Country of publisher: United Kingdom
LCC subjects: Medicine: Medicine (General); Science: Biology (General): Genetics
Website: https://www.embopress.org/journal/17574684

About the journal