Cisplatin Induced SIADH in Patients Receiving Concurrent Chemoradiation Therapy: A Rare Clinical Observation

Abstract

The Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) can be attributed to various causes such as CNS disorders like head trauma, stroke, pulmonary lesions like TB, bacterial pneumonia, as paraneoplastic syndromes in malignancies, drugs like antidepressants, antineoplastics like cyclophosphamide, vincristine, vinblastine, bortezomib, carboplatin and others. Cisplatin induced SIADH is very uncommon and hence, scarcely reported in literature. Here, we report two cases of dilutional hyponatremia secondary to SIADH that developed in two patients receiving radiotherapy with concomitant cisplatin.

Keywords

• chemotherapy
• concomitant
• dilutional hyponatremia