Disease-Specific Survival of Type I and Type II Epithelial Ovarian Cancers—Stage Challenges Categorical Assignments of Indolence & Aggressiveness
Edward J. Pavlik,
Christopher Smith,
Taylor S. Dennis,
Elizabeth Harvey,
Bin Huang,
Quan Chen,
Dava West Piecoro,
Brian T. Burgess,
Anthony McDowell,
Justin Gorski,
Lauren A. Baldwin,
Rachel W. Miller,
Christopher P. DeSimone,
Charles Dietrich,
Holly H. Gallion,
Frederick R. Ueland,
John R. van Nagell
Affiliations
Edward J. Pavlik
Department of Obstetrics & Gynecology, University of Kentucky, Lexington, KY 40536, USA
Christopher Smith
Department of Obstetrics & Gynecology, University of Kentucky, Lexington, KY 40536, USA
Taylor S. Dennis
Denison University, Granville, OH 43023, USA
Elizabeth Harvey
Department of Obstetrics & Gynecology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 43023, USA
Bin Huang
Division of Cancer Biostatistics, College of Public Health & Biostatistics Shared Resource Facility, Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA
Quan Chen
Division of Cancer Biostatistics, College of Public Health & Biostatistics Shared Resource Facility, Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA
Dava West Piecoro
Department of Pathology and the Markey Cancer Center, Lexington, KY 40536, USA
Brian T. Burgess
Department of Obstetrics & Gynecology, University of Kentucky, Lexington, KY 40536, USA
Anthony McDowell
Department of Obstetrics & Gynecology, University of Kentucky, Lexington, KY 40536, USA
Justin Gorski
Department of Obstetrics & Gynecology, University of Kentucky, Lexington, KY 40536, USA
Lauren A. Baldwin
Department of Obstetrics & Gynecology, University of Kentucky, Lexington, KY 40536, USA
Rachel W. Miller
Department of Obstetrics & Gynecology, University of Kentucky, Lexington, KY 40536, USA
Christopher P. DeSimone
Department of Obstetrics & Gynecology, University of Kentucky, Lexington, KY 40536, USA
Charles Dietrich
Department of Obstetrics & Gynecology, University of Kentucky, Lexington, KY 40536, USA
Holly H. Gallion
Department of Obstetrics & Gynecology, University of Kentucky, Lexington, KY 40536, USA
Frederick R. Ueland
Department of Obstetrics & Gynecology, University of Kentucky, Lexington, KY 40536, USA
John R. van Nagell
Department of Obstetrics & Gynecology, University of Kentucky, Lexington, KY 40536, USA
Epithelial ovarian cancers (EOC) consist of several sub-types based on histology, clinical, molecular and epidemiological features that are termed “histo-types”, which can be categorized into less aggressive Type I and more aggressive Type II malignancies. This investigation evaluated the disease-specific survival (DSS) of women with Type I and II EOC using histo-type, grade, and stage. A total of 47,789 EOC cases were identified in the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) data. Survival analysis and log rank test were performed to identify a 2-tiered classification (grade 1 vs. grade 2 & 3) for serous EOC. DSS of early stage serous EOC for grade 2 was significantly different from grade 3 indicating that a 2-tier classification for serous EOC applied only to late stage. DSS of Type I EOC was much better than Type II. However, DSS was 33−52% lower with late stage Type I than with early stage Type I indicating that Type I ovarian cancers should not be considered indolent. Early stage Type II EOC had much better DSS than late stage Type II stressing that stage has a large role in survival of both Type I and II EOC.
