The potential value of CDV3 in the prognosis evaluation in Hepatocellular carcinoma

Heng Xiao; Baoyong Zhou; Ning Jiang; Yunshi Cai; Xiongwei Liu; Zhengrong Shi; Ming Li; Chengyou Du

Genes and Diseases (Jun 2018)

The potential value of CDV3 in the prognosis evaluation in Hepatocellular carcinoma

Heng Xiao,
Baoyong Zhou,
Ning Jiang,
Yunshi Cai,
Xiongwei Liu,
Zhengrong Shi,
Ming Li,
Chengyou Du

Affiliations

Heng Xiao: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, People’s Republic of China
Baoyong Zhou: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, People’s Republic of China
Ning Jiang: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, People’s Republic of China
Yunshi Cai: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, People’s Republic of China
Xiongwei Liu: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, People’s Republic of China
Zhengrong Shi: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, People’s Republic of China
Ming Li: Corresponding author. Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of China. Fax: +86 23 6881 1487.; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, People’s Republic of China
Chengyou Du: Corresponding author. Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of China. Fax: +86 23 6881 1487.; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, People’s Republic of China

Journal volume & issue: Vol. 5, no. 2
pp. 167 – 171

Abstract

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CDV3 is correlated with tumorigenesis and may affect some biological process in cancer. In this study, we explore the role of CDV3 in HCC. According to the TCGA data base, CDV3 is over-expressed in HCC tissues. Up-regulation of CDV3 is correlated with lower over-all survival rate in HCC patients. In HCC samples from our hospital, CDV3 is also enriched in cancer tissues and CDV3 expression associated with HCC pathological T stage. What is more, higher CDV3 expression could forecast poor survival rate in HCC patients. In conclusion, CDV3 is a biomarker of HCC and could be a potential therapeutic target. Keywords: Carnitine deficiency-associated gene expressed in ventricle 3(CDV3), Hepatocellular carcinoma (HCC), The cancer genome Atlas (TCGA), Prognostic value, Therapeutic biomarker

Published in Genes and Diseases

ISSN: 2352-3042 (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Medicine: Medicine (General); Science: Biology (General): Genetics
Website: https://www.keaipublishing.com/en/journals/genes-and-diseases/

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