A novel manganese/iodine-catalyzed Ortoleva-King type protocol for the synthesis of imidazo[1,2-a]pyridines and Zolimidine

Abstract

The first manganese-iodine catalyzed Ortoleva-King type protocol for the synthesis of imidazo[1,2-a]pyridines has been established. This interesting methodology involves the use of less toxic, readily available and easy to handle MnO2 and molecular iodine as the catalytic system. A wide range of aromatic ketones and 2-aminopyridines were tolerated well in this reaction to afford a variety of imidazo[1,2-a]pyridines in moderate to good yields. This one-pot method is efficient towards the direct synthesis of the gastro protective drug, Zolimidine.

Keywords

• Imidazo[1,2-a]pyridines
• Oroleva-King type reaction
• Manganese
• Iodine
• Zolimidine