Mitochondrial Homeostasis and Cellular Senescence

Panagiotis  V.S. Vasileiou; Konstantinos Evangelou; Konstantinos Vlasis; Georgios Fildisis; Mihalis  I. Panayiotidis; Efstathios Chronopoulos; Panagiotis-Georgios Passias; Mirsini Kouloukoussa; Vassilis  G. Gorgoulis; Sophia Havaki

doi:10.3390/cells8070686

Cells (Jul 2019)

Mitochondrial Homeostasis and Cellular Senescence

Panagiotis V.S. Vasileiou,
Konstantinos Evangelou,
Konstantinos Vlasis,
Georgios Fildisis,
Mihalis I. Panayiotidis,
Efstathios Chronopoulos,
Panagiotis-Georgios Passias,
Mirsini Kouloukoussa,
Vassilis G. Gorgoulis,
Sophia Havaki

Affiliations

Panagiotis V.S. Vasileiou: Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Str., 11527 Athens, Greece
Konstantinos Evangelou: Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Str., 11527 Athens, Greece
Konstantinos Vlasis: Department of Anatomy, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Str., 11527 Athens, Greece
Georgios Fildisis: Nursing School, National and Kapodistrian University of Athens, 123 Papadiamantopoulou Str., 11527 Athens, Greece
Mihalis I. Panayiotidis: Department of Applied Sciences, Northumbria University, Newcastle upon Tyne, NE1 8ST Newcastle, UK
Efstathios Chronopoulos: Second Department of Orthopaedics, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Str., 11527 Athens, Greece
Panagiotis-Georgios Passias: Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Str., 11527 Athens, Greece
Mirsini Kouloukoussa: Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Str., 11527 Athens, Greece
Vassilis G. Gorgoulis: Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Str., 11527 Athens, Greece
Sophia Havaki: Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Str., 11527 Athens, Greece

DOI: https://doi.org/10.3390/cells8070686
Journal volume & issue: Vol. 8, no. 7
p. 686

Abstract

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Cellular senescence refers to a stress response aiming to preserve cellular and, therefore, organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic mechanisms, manifested as impaired mitochondrial biogenesis, metabolism and dynamics, has emerged as a hallmark of cellular senescence. On the other hand, impaired mitostasis has been suggested to induce cellular senescence. This review aims to provide an overview of homeostatic mechanisms operating within mitochondria and a comprehensive insight into the interplay between cellular senescence and mitochondrial dysfunction.

Published in Cells

ISSN: 2073-4409 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General): Cytology
Website: https://www.mdpi.com/journal/cells

About the journal

Abstract

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