A structural and dynamic model for the assembly of Replication Protein A on single-stranded DNA

Luke A. Yates; Ricardo J. Aramayo; Nilisha Pokhrel; Colleen C. Caldwell; Joshua A. Kaplan; Rajika L. Perera; Maria Spies; Edwin Antony; Xiaodong Zhang

doi:10.1038/s41467-018-07883-7

Nature Communications (Dec 2018)

A structural and dynamic model for the assembly of Replication Protein A on single-stranded DNA

Luke A. Yates,
Ricardo J. Aramayo,
Nilisha Pokhrel,
Colleen C. Caldwell,
Joshua A. Kaplan,
Rajika L. Perera,
Maria Spies,
Edwin Antony,
Xiaodong Zhang

Affiliations

Luke A. Yates: Section of Structural Biology, Department of Medicine, Imperial College London
Ricardo J. Aramayo: Section of Structural Biology, Department of Medicine, Imperial College London
Nilisha Pokhrel: Department of Biological Sciences, Marquette University
Colleen C. Caldwell: Department of Biochemistry, Carver College of Medicine, University of Iowa
Joshua A. Kaplan: Section of Structural Biology, Department of Medicine, Imperial College London
Rajika L. Perera: Section of Structural Biology, Department of Medicine, Imperial College London
Maria Spies: Department of Biochemistry, Carver College of Medicine, University of Iowa
Edwin Antony: Department of Biological Sciences, Marquette University
Xiaodong Zhang: Section of Structural Biology, Department of Medicine, Imperial College London

DOI: https://doi.org/10.1038/s41467-018-07883-7
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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Replication Protein A (RPA) coats single stranded DNA (ssDNA) generated during DNA recombination, replication and repair. Here the authors present a structural model suggesting how RPA’s DNA-binding domains promote cooperative assembly of multiple RPAs on long ssDNA.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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