Enzymatically promoted release of organic molecules linked to magnetic nanoparticles

Abstract

Magnetite-based magnetic nanoparticles have been successfully coupled to an organic system constituted of a fluorescent molecule, a tripeptide specifier and a spacer. The system is able to selectively release the fluorescent molecule upon targeted enzymatic hydrolysis promoted by a lysine/arginine specific protease.

Keywords

• drug delivery
• enzyme catalysis
• magnetic nanoparticles
• magnetic properties
• peptides