Jornal de Pediatria (Jun 2016)

A double-blinded randomized trial on growth and feeding tolerance with Saccharomyces boulardii CNCM I-745 in formula-fed preterm infants

  • Lingfen Xu,
  • Yun Wang,
  • Yang Wang,
  • Jianhua Fu,
  • Mei Sun,
  • Zhiqin Mao,
  • Yvan Vandenplas

DOI
https://doi.org/10.1016/j.jped.2015.08.013
Journal volume & issue
Vol. 92, no. 3
pp. 296 – 301

Abstract

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Abstract Objective: The use of probiotics is increasingly popular in preterm neonates, as they may prevent necrotizing enterocolitis sepsis and improve growth and feeding tolerance. There is only limited literature on Saccharomyces boulardii CNCM I-745 (S. boulardii) in preterm infants. Method: A prospective, randomized, case-controlled trial with the probiotic S. boulardii (50 mg/kg twice daily) was conducted in newborns with a gestational age of 30-37 weeks and a birth weight between 1500 and 2500 g. Results: 125 neonates were enrolled; 63 in the treatment and 62 in the control group. Weight gain (16.14 ± 1.96 vs. 10.73 ± 1.77 g/kg/day, p 30 weeks old.

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