Nature Communications (Jan 2019)
Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis
- Hao Chen,
- Bo Hu,
- Xiao Lv,
- Shouan Zhu,
- Gehua Zhen,
- Mei Wan,
- Amit Jain,
- Bo Gao,
- Yu Chai,
- Mi Yang,
- Xiao Wang,
- Ruoxian Deng,
- Lei Wang,
- Yong Cao,
- Shuangfei Ni,
- Shen Liu,
- Wen Yuan,
- Huajiang Chen,
- Xinzhong Dong,
- Yun Guan,
- Huilin Yang,
- Xu Cao
Affiliations
- Hao Chen
- Department of Orthopaedic Surgery, The Johns Hopkins University
- Bo Hu
- Department of Orthopaedic Surgery, The Johns Hopkins University
- Xiao Lv
- Department of Orthopaedic Surgery, The Johns Hopkins University
- Shouan Zhu
- Department of Orthopaedic Surgery, The Johns Hopkins University
- Gehua Zhen
- Department of Orthopaedic Surgery, The Johns Hopkins University
- Mei Wan
- Department of Orthopaedic Surgery, The Johns Hopkins University
- Amit Jain
- Department of Orthopaedic Surgery, The Johns Hopkins University
- Bo Gao
- Department of Orthopaedic Surgery, The Johns Hopkins University
- Yu Chai
- Department of Orthopaedic Surgery, The Johns Hopkins University
- Mi Yang
- Department of Orthopaedic Surgery, The Johns Hopkins University
- Xiao Wang
- Department of Orthopaedic Surgery, The Johns Hopkins University
- Ruoxian Deng
- Department of Orthopaedic Surgery, The Johns Hopkins University
- Lei Wang
- Department of Orthopaedic Surgery, The Johns Hopkins University
- Yong Cao
- Department of Orthopaedic Surgery, The Johns Hopkins University
- Shuangfei Ni
- Department of Orthopaedic Surgery, The Johns Hopkins University
- Shen Liu
- Department of Orthopaedic Surgery, The Johns Hopkins University
- Wen Yuan
- Section of Spine Surgery, Department of Orthopaedics, Changzheng Hospital, Second Military Medical University
- Huajiang Chen
- Section of Spine Surgery, Department of Orthopaedics, Changzheng Hospital, Second Military Medical University
- Xinzhong Dong
- Howard Hughes Medical Institute and The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, The Johns Hopkins University School of Medicine
- Yun Guan
- Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine
- Huilin Yang
- Department of Orthopaedic Surgery, First Affiliated Hospital of Soochow University
- Xu Cao
- Department of Orthopaedic Surgery, The Johns Hopkins University
- DOI
- https://doi.org/10.1038/s41467-018-08097-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Bone is innervated, and its turnover is affected by sympathetic nerve activity. Here, the authors show that prostaglandin E2, secreted by osteoblasts, activates the EP4 receptor on sensory nerves, inhibiting sympathetic nerve activity and modulating bone formation in mice.
