Therapeutic role of exosomes and conditioned medium in keloid and hypertrophic scar and possible mechanisms

Yixiu Zhong; Youfan Zhang; Aijiao Yu; Aijiao Yu; Zhiwen Zhang; Zhiwen Zhang; Zhenjun Deng; Kaifen Xiong; Qi Wang; Jianglin Zhang

doi:10.3389/fphys.2023.1247734

Frontiers in Physiology (Sep 2023)

Therapeutic role of exosomes and conditioned medium in keloid and hypertrophic scar and possible mechanisms

Yixiu Zhong,
Youfan Zhang,
Aijiao Yu,
Aijiao Yu,
Zhiwen Zhang,
Zhiwen Zhang,
Zhenjun Deng,
Kaifen Xiong,
Qi Wang,
Jianglin Zhang

Affiliations

Yixiu Zhong: Department of Dermatology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China
Youfan Zhang: Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, China
Aijiao Yu: Department of Dermatology, Dermatology Hospital, Southern Medical University, Guangzhou, China
Aijiao Yu: Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou, China
Zhiwen Zhang: Department of Dermatology, Dermatology Hospital, Southern Medical University, Guangzhou, China
Zhiwen Zhang: Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou, China
Zhenjun Deng: Department of Dermatology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China
Kaifen Xiong: Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China
Qi Wang: Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, China
Jianglin Zhang: Department of Dermatology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China

DOI: https://doi.org/10.3389/fphys.2023.1247734
Journal volume & issue: Vol. 14

Abstract

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Exosomes, ranging from 40 to 160 nm in diameter, are extracellular lipid bilayer microvesicles that regulate the body’s physiological and pathological processes and are secreted by cells that contain proteins, nucleic acids, amino acids and other metabolites. Previous studies suggested that mesenchymal stem cell (MSC)-derived exosomes could either suppress or support keloid and hypertrophic scar progression. Although previous research has identified the potential value of MSC-exosomes in keloid and hypertrophic scar, a comprehensive analysis of different sources of MSC-exosome in keloid and hypertrophic scar is still lacking. This review mainly discusses different insights regarding the roles of MSC-exosomes in keloid and hypertrophic scar treatment and summarizes possible underlying mechanisms.

Published in Frontiers in Physiology

ISSN: 1664-042X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Physiology
Website: https://www.frontiersin.org/journals/physiology

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Abstract

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