Acta Dermato-Venereologica (Jan 2023)
Itching in Atopic Dermatitis: Patient- and Physician-reported Outcomes in the German Atopic Dermatitis Registry TREATgermany
- Elke Weisshaar,
- Philipp Bentz,
- Christian Apfelbacher,
- Eva Haufe,
- Luise Heinrich,
- Annice Heratizadeh,
- Susanne Abraham,
- Inken Harder,
- Andreas Kleinheinz,
- Andreas Wollenberg,
- Knut Schäkel,
- Franca Wiemers,
- Julia Ertner,
- Matthias Augustin,
- Julia Wildberger,
- Ralph von Kiedrowski,
- Margitta Worm,
- Alexander Zink,
- Isaak Effendy,
- Andrea Asmussen,
- Mario Pawlak,
- Michael Sticherling,
- Melanie Hilgers,
- Christiane Handrick,
- Sven Quist,
- Beate Schwarz,
- Magnus Bell,
- Petra Staubach-Renz,
- Sung-Hei Hong-Weldemann,
- Bernhard Homey,
- Jens-Joachim Brücher,
- Stephan Weidinger,
- Thomas Werfel,
- Jochen Schmitt
Affiliations
- Elke Weisshaar
- Occupational Dermatology, Department of Dermatology, University of Heidelberg
- Philipp Bentz
- Occupational Dermatology, Department of Dermatology, University of Heidelberg
- Christian Apfelbacher
- Institute of Social Medicine and Health Systems Research, Otto von Guericke University Magdeburg, Magdeburg, Germany; Institute for Epidemiology and Preventive Medicine/Medical Sociology, University of Regensburg, Regensburg, Germany
- Eva Haufe
- Center of Evidence-based Healthcare, University Hospital and Medical Faculty Carl Gustav Carus, TU Dresden
- Luise Heinrich
- 4. Center of Evidence-based Healthcare, University Hospital and Medical Faculty Carl Gustav Carus, TU Dresden
- Annice Heratizadeh
- Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover
- Susanne Abraham
- Department of Dermatology, University Allergy Center, Medical Faculty Carl Gustav Carus, TU Dresden
- Inken Harder
- Center for Inflammatory Skin Diseases, Department of Dermatology and Allergy, University Hospital Schleswig-Holstein, Campus Kiel
- Andreas Kleinheinz
- Clinics for Dermatology, Elbe Klinikum Buxtehude
- Andreas Wollenberg
- Clinics and Outpatient Clinics for Dermatology and Allergy, LMU Munich
- Knut Schäkel
- Department of Dermatology, University of Heidelberg
- Franca Wiemers
- Practice Dr. med. Franca Wiemers, Leipzig
- Julia Ertner
- Practice Dr. med. Konstantin Ertner, Nuernberg
- Matthias Augustin
- Institute for Health Services Research in Dermatology, University Medical Center Hamburg Eppendorf
- Julia Wildberger
- Practice Dr. med. Julia Wildberger, Hautmedizin, Bad Soden
- Ralph von Kiedrowski
- Focus Practice for chronic inflammatory dermatoses, skin cancer and allergology and also Study Center CMS3 (Company for Medical Study and Service), Selters/Westerwald
- Margitta Worm
- Department of Dermatology, Allergy and Venereology, Charité Berlin
- Alexander Zink
- Isaak Effendy
- Department of Dermatology, OWL University Hospital of Bielefeld University, Campus Clinic Bielefeld
- Andrea Asmussen
- Practice Dr. med. Andrea Asmussen, Dermatology at Lesum, Bremen
- Mario Pawlak
- Practice Dr. med. Anika Hünermund and Mario Pawlak, Heiligenstadt
- Michael Sticherling
- 21. Department of Dermatology, German Center for Immunotherapy, University of Erlangen
- Melanie Hilgers
- Clinics for Dermatology and Allergy, University Hospital Aachen
- Christiane Handrick
- Practice Dr. med. Christiane Handrick, Berlin
- Sven Quist
- Dermatology Clinic, Helix Medical Excellence Center, Mainz
- Beate Schwarz
- Practice Dr. med. Beate Schwarz, Langenau
- Magnus Bell
- Practice Dr. med. Magnus Bell, Andernach
- Petra Staubach-Renz
- Clinic for Dermatology, University Hospital, Mainz
- Sung-Hei Hong-Weldemann
- Practice Dr. med. Sung-Hei Hong-Weldemann, Freiburg
- Bernhard Homey
- Department of Dermatology and Allergology, University Hospital Duesseldorf
- Jens-Joachim Brücher
- Practice Dr. med. Jens-Joachim Brücher, Hautambulatorium Magdeburg
- Stephan Weidinger
- Center for Inflammatory Skin Diseases, Department of Dermatology and Allergy, University Hospital Schleswig-Holstein, Campus Kiel
- Thomas Werfel
- Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover
- Jochen Schmitt
- Center of Evidence-based Healthcare, University Hospital and Medical Faculty Carl Gustav Carus, TU Dresden
- DOI
- https://doi.org/10.2340/actadv.v103.4426
- Journal volume & issue
-
Vol. 103
Abstract
TREATgermany is an investigator-initiated prospective disease registry. It investigates physician- and patient-reported disease severity (Eczema Area and Severity Index (EASI), objective Scoring Atopic Dermatitis (oSCORAD), Investigator Global Assessment, Patient-Oriented Eczema Measure (POEM), Patient Global Assessment (PGA)), patient-reported symptoms (itch, sleep loss, depressive symptoms), therapy courses and dermatological quality of life (DLQI) in moderate-to-severe atopic dermatitis with SCORAD > 20. 1,134 atopic dermatitis patients (mean age 41.0 ± 14.7 years, 42.5% females) were enrolled by 40 German recruiting sites (dermatological clinics and practices) between June 2016 and April 2021. The current analysis focuses on itch scores obtained with a numerical rating scale (NRS)) documented for the previous 3 days prior to baseline visit. The results show that 97.2% (1,090 of 1,121) patients experienced itch. Itch severity correlated moderately with severity of atopic dermatitis oSCORAD (rho = 0.44 (0.39–0.48)) and EASI score (rho = 0.41 (0.36–0.46)). A strong correlation was found with self-reported disease severity as PGA (rho = 0.68 (0.65–0.71)), POEM sum score (rho = 0.66 (0.63–0.69)) and dermatological quality of life impairment DLQI (rho = 0.61 (0.57–0.65)). Itch as a subjective complaint is more closely correlated with patient-reported outcomes than with objective assessments by the physician.
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