Disparity in risk factors of ischemic stroke in four coastal-area hospitals in China
Luji Liu,
Yuhua Fan,
Zhaolu Wang,
Fei Liu,
Xin Wang,
Jinsheng Fu,
Zhenzhong Li,
Huilian Sun,
Yuanyuan Du,
Jie Yang,
Xiaoyan Fan,
Bo Liu,
Lihong Zhang
Affiliations
Luji Liu
Department of Neurology, the Second Hospital of Hebei Medical University, Shijiazhuang, China; The Key Laboratory of Neurology (Hebei Medical University), Ministry of Education, Shijiazhuang, China
Yuhua Fan
Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, China
Zhaolu Wang
Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Fei Liu
Department of Orthopaedics, The First Hospital of Qin Huang Dao, Qinhuangdao, China
Xin Wang
Department of Neurology, The Qingdao Municipal Hospital, Qingdao, China
Jinsheng Fu
Department of Neurology, the Second Hospital of Hebei Medical University, Shijiazhuang, China; The Key Laboratory of Neurology (Hebei Medical University), Ministry of Education, Shijiazhuang, China
Zhenzhong Li
Department of Neurology, the Second Hospital of Hebei Medical University, Shijiazhuang, China; The Key Laboratory of Neurology (Hebei Medical University), Ministry of Education, Shijiazhuang, China
Huilian Sun
Department of Clinical Epidemiology and Evidence-Based Medicine, the Second Hospital of Hebei Medical University, Shijiazhuang, China
Yuanyuan Du
Department of Neurology, the Second Hospital of Hebei Medical University, Shijiazhuang, China; The Key Laboratory of Neurology (Hebei Medical University), Ministry of Education, Shijiazhuang, China
Jie Yang
Maternal-Infant Care Research Centre (MiCare), Mount Sinai Hospital, Toronto, ON, Canada
Xiaoyan Fan
School of Public Health, Hebei Medical University, Shijiazhuang, China
Bo Liu
Department of Neurology, the Second Hospital of Hebei Medical University, Shijiazhuang, China; The Key Laboratory of Neurology (Hebei Medical University), Ministry of Education, Shijiazhuang, China
Lihong Zhang
Department of Neurology, the Second Hospital of Hebei Medical University, Shijiazhuang, China; The Key Laboratory of Neurology (Hebei Medical University), Ministry of Education, Shijiazhuang, China; Corresponding author. Department of Neurology, The Second Hospital of Hebei Medical University, 215 Heping West Road, Shijiazhuang, 050000, China.
Background: Currently, ischemic stroke is the leading cause of death in China. To compare regional differences of ischemic stroke, we analyzed the clinical characteristics of patients with ischemic stroke in four regionally representative hospitals in China. Methods: We conducted a retrospective study at four tertiary hospitals in east China, with regionally representative patients. The associated factors include hypertension, diabetes mellitus, coronary heart disease, hyperlipidemia and a combination of these factors. The standardized ratio (SR), estimated as the observed number divided by the expected number, computed as the sum of predicted probabilities from a multivariable logistic regression model derived using data from all other cities, was used to compare to average levels. Results: A total of 34,707 patients were included. The number of patients increased with age in all four hospitals and patients were predominantly male. The number of ischemic stroke cases with related factors increased with age, except for hyperlipidemia. There was no significant gender difference when multiple related factors existed simultaneously. Coronary heart disease had a more significant impact on ischemic stroke in Qingdao Municipal Hospital and the First Hospital of Qinhuangdao, while hyperlipidemia had a significant influence on ischemic stroke in the First Hospital of Qinhuangdao. Conclusions: At four hospitals in east China, with the increase of age, the risk factors associated with ischemic stroke increased, and the distribution of ischemic stroke-related factors showed regional differences.
