Clinical case of long-term use of durvalumab in the treatment of advanced small-cell lung cancer

Abstract

Over the last few decades there was a little progress in the treatment of small cell lung cancer (SCLC). But now the approaches are changing with immune checkpoint inhibitors coming into clinical practice. Using a combination of immunotherapy with the standard chemotherapy in the first line of extensive stage small cell lung cancer (ES-SCLC) results in significant overall survival improvement, for the first time the median survival in these patients exceeded one year. Here we present a clinical case of ES-SCLC patient treated with durvalumab, a monoclonal antibody against PD-L1, in combination with etoposide and carboplatin in the CASPIAN clinical trial. In the CASPIAN trial more than 20% of patients treated with durvalumab stay alive more than two years. In the presented case we also reported durable control of the disease, the patient continued to receive durvalumab of more than two years with acceptable tolerability.

Keywords

• small cell lung cancer
• immune checkpoint inhibitor
• immunotherapy
• durvalumab