TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens

Rikio Yabe; Soo-Hyun Chung; Masanori A. Murayama; Sachiko Kubo; Kenji Shimizu; Yukiko Akahori; Takumi Maruhashi; Akimasa Seno; Tomonori Kaifu; Shinobu Saijo; Yoichiro Iwakura

doi:10.1038/s41467-020-20307-9

Nature Communications (Jan 2021)

TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens

Rikio Yabe,
Soo-Hyun Chung,
Masanori A. Murayama,
Sachiko Kubo,
Kenji Shimizu,
Yukiko Akahori,
Takumi Maruhashi,
Akimasa Seno,
Tomonori Kaifu,
Shinobu Saijo,
Yoichiro Iwakura

Affiliations

Rikio Yabe: Center for Animal Disease Models, Research Institute for Biomedical Sciences (RIBS), Tokyo University of Science
Soo-Hyun Chung: Center for Animal Disease Models, Research Institute for Biomedical Sciences (RIBS), Tokyo University of Science
Masanori A. Murayama: Center for Animal Disease Models, Research Institute for Biomedical Sciences (RIBS), Tokyo University of Science
Sachiko Kubo: Center for Animal Disease Models, Research Institute for Biomedical Sciences (RIBS), Tokyo University of Science
Kenji Shimizu: Center for Animal Disease Models, Research Institute for Biomedical Sciences (RIBS), Tokyo University of Science
Yukiko Akahori: Medical Mycobiology Research Center, Chiba University
Takumi Maruhashi: Center for Animal Disease Models, Research Institute for Biomedical Sciences (RIBS), Tokyo University of Science
Akimasa Seno: Center for Animal Disease Models, Research Institute for Biomedical Sciences (RIBS), Tokyo University of Science
Tomonori Kaifu: Center for Animal Disease Models, Research Institute for Biomedical Sciences (RIBS), Tokyo University of Science
Shinobu Saijo: Medical Mycobiology Research Center, Chiba University
Yoichiro Iwakura: Center for Animal Disease Models, Research Institute for Biomedical Sciences (RIBS), Tokyo University of Science

DOI: https://doi.org/10.1038/s41467-020-20307-9
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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TARM1 is a LILR family member that drives cell signalling via interactions with FcRγ. Here the authors show that TARM1 binds collagens to activate dendritic cells and thereby is an effector of inflammatory arthritis, plus provide a soluble TARM-Fc fusion protein that can limit collagen-induced arthritis in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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