Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi008-A) from a patient with Spinocerebellar Ataxia Type 3

Bo Li; Yingxin Wang; Yitong Yang; Didi Shan; Jianing Li; Hongxu Wang; Xiaohan Sun; Zexin Zhan; Xinbo Ji; Yao Tang; Yichang Jiao; Bo Kong; Bo Gao; Ping Sun; Fuchen Liu; Yu Wang

doi:10.1016/j.scr.2025.103675

Stem Cell Research (Apr 2025)

Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi008-A) from a patient with Spinocerebellar Ataxia Type 3

Bo Li,
Yingxin Wang,
Yitong Yang,
Didi Shan,
Jianing Li,
Hongxu Wang,
Xiaohan Sun,
Zexin Zhan,
Xinbo Ji,
Yao Tang,
Yichang Jiao,
Bo Kong,
Bo Gao,
Ping Sun,
Fuchen Liu,
Yu Wang

Affiliations

Bo Li: Department of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining, Shandong, China
Yingxin Wang: Department of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, China
Yitong Yang: School of Nursing, Jining Medical University, Jining, Shandong, China
Didi Shan: Department of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, China
Jianing Li: Department of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, China
Hongxu Wang: Department of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, China
Xiaohan Sun: School of Nursing, Jining Medical University, Jining, Shandong, China
Zexin Zhan: School of Nursing, Jining Medical University, Jining, Shandong, China
Xinbo Ji: School of Nursing, Jining Medical University, Jining, Shandong, China
Yao Tang: School of Nursing, Jining Medical University, Jining, Shandong, China
Yichang Jiao: School of Nursing, Jining Medical University, Jining, Shandong, China
Bo Kong: Department of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining, Shandong, China
Bo Gao: Department of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining, Shandong, China
Ping Sun: Prenatal Diagnostic Center of Obstetrics and Department of Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong, China
Fuchen Liu: Department of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, China; Corresponding authors.
Yu Wang: Prenatal Diagnostic Center of Obstetrics and Department of Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong, China; Corresponding authors.

DOI: https://doi.org/10.1016/j.scr.2025.103675
Journal volume & issue: Vol. 84
p. 103675

Abstract

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Abnormal trinucleotide CAG repeat expansions in exon 10 of the ataxin-3 (ATXN3) gene has been identified as the cause of Spinocerebellar Ataxia Type 3 (SCA3). We generated and characterized a human induced pluripotent stem cell (iPSC) line from skin fibroblasts of a patient with genetically confirmed SCA3. The pluripotency of these iPSCs was verified by the expression of several undifferentiated hPSCs markers at both RNA and protein levels, as well as their capability to differentiate into all three germ layers.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.sciencedirect.com/journal/stem-cell-research

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