Molecular Targets of Brown Algae Phlorotannins for the Therapy of Inflammatory Processes of Various Origins
Natalya N. Besednova,
Boris G. Andryukov,
Tatyana S. Zaporozhets,
Tatyana A. Kuznetsova,
Sergey P. Kryzhanovsky,
Svetlana P. Ermakova,
Irina V. Galkina,
Mikhail Yu. Shchelkanov
Affiliations
Natalya N. Besednova
Somov Research Institute of Epidemiology and Microbiology by Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 690087 Vladivostok, Russia
Boris G. Andryukov
Somov Research Institute of Epidemiology and Microbiology by Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 690087 Vladivostok, Russia
Tatyana S. Zaporozhets
Somov Research Institute of Epidemiology and Microbiology by Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 690087 Vladivostok, Russia
Tatyana A. Kuznetsova
Somov Research Institute of Epidemiology and Microbiology by Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 690087 Vladivostok, Russia
Sergey P. Kryzhanovsky
Medical Association of the Far Eastern Branch of the Russian Academy of Sciences, 690022 Vladivostok, Russia
Svetlana P. Ermakova
Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 690022 Vladivostok, Russia
Irina V. Galkina
School of Medicine, Far Eastern Federal University (FEFU), 690091 Vladivostok, Russia
Mikhail Yu. Shchelkanov
Somov Research Institute of Epidemiology and Microbiology by Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 690087 Vladivostok, Russia
Inflammatory reactions are part of a complex biological response that plays a vital role in the appearance of various stimuli resulting from tissue and cell damage, the invasion of pathogenic bacteria, and the formation of the subsequent adaptive immune response. The production of many triggers and mediators of inflammation, which are inducers of pro-inflammatory factors, is controlled by numerous differentiation programs, through which inflammation is resolved and tissue homeostasis is restored. However, prolonged inflammatory responses or dysregulation of pro-inflammatory mechanisms can lead to chronic inflammation. Modern advances in biotechnology have made it possible to characterize the anti-inflammatory activity of phlorotannins, polyphenolic compounds from brown seaweed, and the mechanisms by which they modulate the inflammatory response. The purpose of this review is to analyze and summarize the results of numerous experimental in vitro and in vivo studies, illustrating the regulatory mechanisms of these compounds, which have a wide range of biological effects on the body. The results of these studies and the need for further research are discussed.
