Trunk fat and leg fat in relation to free triiodothyronine in euthyroid postmenopausal women

Xiaomin Nie; Yiting Xu; Xiaojing Ma; Yun Shen; Yufei Wang; Yuqian Bao

doi:10.1530/EC-19-0394

Endocrine Connections (Oct 2019)

Trunk fat and leg fat in relation to free triiodothyronine in euthyroid postmenopausal women

Xiaomin Nie,
Yiting Xu,
Xiaojing Ma,
Yun Shen,
Yufei Wang,
Yuqian Bao

Affiliations

Xiaomin Nie: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China
Yiting Xu: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China
Xiaojing Ma: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China
Yun Shen: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China
Yufei Wang: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China
Yuqian Bao: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China

DOI: https://doi.org/10.1530/EC-19-0394
Journal volume & issue: Vol. 8, no. 10
pp. 1425 – 1432

Abstract

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Background: A high level of free triiodothyronine (FT3) within the referen ce range may be a potential metabolic risk marker. However, the relationship between different fat depots and FT3 has remained unclear. Objective: We aimed to explore the relationships between segmental fat di stribution and FT3 in euthyroid middle-aged and elderly men and postmenopausal women. Methods: A total of 891 subjects (394 men and 497 women) were enrolled. A bioelectrical impedance analyzer was used to measure total, trunk, arm and le g fat mass (FM) and fat percentage (fat%). The leg fat mass to trunk fat mass ratio (LTR) was calculated to evaluate the relative distribution of leg fat compared with tha t of trunk fat. Thyroid hormones were measured by electrochemical luminescence immunoassay. Results: FT3 in men did not change significantly with increases in LTR q uartiles, while FT3 in women decreased significantly (P for trend = 0.004). In multivariate linear regression analysis, multiple metabolic and cardiovascular risk factors we re adjusted. The LTR was negatively related to FT3 in women (P < 0.05). After further mutual adjustment for trunk fat and leg fat parameters, trunk FM and fat% were positively r elated to FT3, while leg FM and fat% were negatively related to FT3 in women (all P < 0.05). Conclusions: In euthyroid postmenopausal women, trunk fat was positively co rrelated with FT3, whereas leg fat was negatively correlated with FT3. Our fin dings supported that a high level of FT3 within the reference range was related to adverse fat distribution.

Published in Endocrine Connections

ISSN: 2049-3614 (Online)
Publisher: Bioscientifica
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: http://www.endocrineconnections.com/

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