Breast Cancer: Targets and Therapy (Jan 2024)

Thyroid Hormone Changes Correlate to Combined Breast Cancer with Primary Thyroid Cancer

  • Jin J,
  • Li J,
  • Liu Y,
  • Shi Q,
  • Zhang B,
  • Ji Y,
  • Hu P

Journal volume & issue
Vol. Volume 16
pp. 15 – 22

Abstract

Read online

Jian Jin, Jie Li, Yonghong Liu, Qingfeng Shi, Bo Zhang, Yanting Ji, Pengfei Hu Thyroid and Breast Surgery Department, Cangzhou Central Hospital, Cangzhou, Hebei, 061000, People’s Republic of ChinaCorrespondence: Jie Li, Thyroid and Breast Surgery Department, Cangzhou Central Hospital, No. 16 Xinhua West Road, Cangzhou, Hebei, 061000, People’s Republic of China, Email [email protected]: Breast cancer and thyroid cancer are two prevalent malignancies in women, and a potential association between the two diseases has been suggested.Methods: This retrospective case-control study was conducted involving 97 patients with breast cancer and thyroid cancer (BC-TC group) and 97 age-matched patients with breast cancer alone (BC group). Thyroid hormone levels, including triiodothyronine (T3), thyroxine (T4), free triiodothyronine (FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH), were analyzed in healthy controls, BC patients, and BC-TC patients.Results: BC-TC patients exhibited a higher rate of estrogen receptor (ER) and progesterone receptor (PR) positivity compared to BC patients. Serum T3 levels were significantly decreased in BC and BC-TC patients compared to healthy controls. However, there was no significant difference in T3 levels between BC and BC-TC patients. Serum TSH levels were significantly higher in BC-TC patients compared to BC patients.Conclusion: ER positivity, PR positivity, and serum TSH levels greater than 4.45 mU/L were independent risk factors for primary thyroid cancer in breast cancer patients.Keywords: breast cancer, thyroid cancer, estrogen receptor, ER

Keywords