The Characteristics, Mechanisms and Therapeutics: Exploring the Role of Gut Microbiota in Obesity

Abstract

Zequn Zhuang,1,* Peng Zhou,1,* Jing Wang,2 Xiaojing Lu,1 Yigang Chen1– 3 1Department of General Surgery, the Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University, Wuxi, People’s Republic of China; 2Jiangnan University Medical Center, Wuxi, People’s Republic of China; 3Wuxi Clinical College, Nantong University, Wuxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yigang Chen, Department of General Surgery, the Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University, Wuxi, People’s Republic of China, Email [email protected]: Presently, obesity has emerged as a significant global public health concern due to its escalating prevalence and incidence rates. The gut microbiota, being a crucial environmental factor, has emerged as a key player in the etiology of obesity. Nevertheless, the intricate and specific interactions between obesity and gut microbiota, along with the underlying mechanisms, remain incompletely understood. This review comprehensively summarizes the gut microbiota characteristics in obesity, the mechanisms by which it induces obesity, and explores targeted therapies centered on gut microbiota restoration.Keywords: gut microbiota, obesity, dysbiosis, metabolism

Keywords

• gut microbiota
• obesity
• dysbiosis
• metabolism