Development of a ternary cyclodextrin–arginine–ciprofloxacin antimicrobial complex with enhanced stability

Marija Vukomanovic; Lea Gazvoda; Mario Kurtjak; Jitka Hrescak; Blaž Jaklic; Laura Moya-Andérico; Maria del Mar Cendra; Eduard Torrents

doi:10.1038/s42003-022-04197-9

Communications Biology (Nov 2022)

Development of a ternary cyclodextrin–arginine–ciprofloxacin antimicrobial complex with enhanced stability

Marija Vukomanovic,
Lea Gazvoda,
Mario Kurtjak,
Jitka Hrescak,
Blaž Jaklic,
Laura Moya-Andérico,
Maria del Mar Cendra,
Eduard Torrents

Affiliations

Marija Vukomanovic: Advanced Materials Department, Institute Jozef Stefan
Lea Gazvoda: Advanced Materials Department, Institute Jozef Stefan
Mario Kurtjak: Advanced Materials Department, Institute Jozef Stefan
Jitka Hrescak: Center for Electronic Microscopy and Microanalysis (CEMM), Institute Jozef Stefan
Blaž Jaklic: Advanced Materials Department, Institute Jozef Stefan
Laura Moya-Andérico: Bacterial Infections: Antimicrobial Therapies, Institute for Bioengineering of Catalonia (IBEC), The Institute of Science and Technology
Maria del Mar Cendra: Bacterial Infections: Antimicrobial Therapies, Institute for Bioengineering of Catalonia (IBEC), The Institute of Science and Technology
Eduard Torrents: Bacterial Infections: Antimicrobial Therapies, Institute for Bioengineering of Catalonia (IBEC), The Institute of Science and Technology

DOI: https://doi.org/10.1038/s42003-022-04197-9
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

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Ternary cyclodextrin- arginine- ciprofloxacin complexes show improved stability and increased efficacy against P. aeruginosa in Galleria mellonella worms.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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