Breast Cancer: Targets and Therapy (Nov 2024)
Analysis of the Effects of Different Chemotherapy Methods on Blood Lipid Levels in Breast Cancer Patients
Abstract
Jiaqi Mu, Mai Zhou, GangJun Jiao Department of General Surgery, Civil Aviation General Hospital, Beijing, 100123, People’s Republic of ChinaCorrespondence: Mai Zhou, Department of General Surgery, Civil Aviation General Hospital, No. 76 Chaoyang Road, Chaoyang District, Beijing, 100123, People’s Republic of China, Email [email protected]: To analyze the impacts of distinct chemotherapy methods on blood lipid levels in breast cancer patients.Methods: Three hundred breast cancer patients were selected as the research subjects. The inclusion time limit was from January 2021 to January 2023, and all received treatment in our hospital. Based on the therapy plan, the patients were divided into group A (epirubicin + cyclophosphamide followed by paclitaxel regimen, 103 premenopausal cases + 61 postmenopausal cases), group B (docetaxel + cyclophosphamide regimen, 41 premenopausal instances + 37 postmenopausal instances), group C (docetaxel + carboplatin regimen, 61 premenopausal instances + 24 postmenopausal instances), comparing the changes in blood lipid levels of patients in each group at pre-therapy and post-therapy, and the abnormality frequency of blood lipids in every group of patients after therapy.Results: After treatment, the triglyceride (TG) levels of the three groups of patients were clearly greater than those at pre-therapy, and the high-density lipoprotein cholesterol (HDL-C) levels were clearly less than before therapy. The levels of low-density lipoprotein cholesterol (LDL-C) in group B and C patients were clearly greater than those before therapy in the same one, while the LDL-C levels in group A were clearly less than those before therapy in the same one; after therapy, the TG levels of patients in group A were clearly less than those in group B, and LDL-C, total Cholesterol (TC) levels were clearly less than that in group B and C (P 0.05).Conclusion: Chemotherapy has adverse effects on the blood lipid levels of premenopausal and postmenopausal breast carcinoma patients and increases the incidence of dyslipidemia. Compared with other regimens, epirubicin+cyclophosphamide sequential paclitaxel regimen has little impact on blood lipid level of breast carcinoma.Keywords: chemotherapy, breast cancer, blood lipids, impact
