Histological Changes and Ghrelin, P-Selectin, and Leptin Parameter in Patients with Hepatic Hydatidosis in Iraq

Abstract

Humans and animals are affected by hydatid cyst disease as a worldwide zoonotic disease, which is caused by the metacestode stage of Echinococcus spp. This study was performed to evaluate the histological change of liver and blood concentrations of biomarkers, such as ghrelin, p-selectin, and leptin, in humans infected with hydatid cyst. A total of 30 surgical specimens of liver and blood of infected humans and 30 healthy individuals as a control group were evaluated. Liver tissue sections in cases infected with hydatid cyst and control group, histological abnormalities in the liver, including fibrosis, increased inflammatory cells, dystrophic areas, and necrosis were compared in this study. In addition, serum leptin levels were significantly lower in patients with hydatid cyst disease than in the control group (P-value<0.05), whereas p-selectin and ghrelin levels significantly decreased in patients (P-value<0.05). The results of this research can be effective in improving and promoting the treatment programs of hydatidosis.

Keywords

• ghrelin
• histological change
• hydatid disease
• kufa
• leptin
• p-selectin