Nature Communications (Jun 2018)
Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations
- Aran Singanayagam,
- Nicholas Glanville,
- Jason L. Girkin,
- Yee Man Ching,
- Andrea Marcellini,
- James D. Porter,
- Marie Toussaint,
- Ross P. Walton,
- Lydia J. Finney,
- Julia Aniscenko,
- Jie Zhu,
- Maria-Belen Trujillo-Torralbo,
- Maria Adelaide Calderazzo,
- Chris Grainge,
- Su-Ling Loo,
- Punnam Chander Veerati,
- Prabuddha S. Pathinayake,
- Kristy S. Nichol,
- Andrew T. Reid,
- Phillip L. James,
- Roberto Solari,
- Peter A. B. Wark,
- Darryl A. Knight,
- Miriam F. Moffatt,
- William O. Cookson,
- Michael R. Edwards,
- Patrick Mallia,
- Nathan W. Bartlett,
- Sebastian L. Johnston
Affiliations
- Aran Singanayagam
- COPD and Asthma Section, National Heart and Lung Institute, Imperial College London
- Nicholas Glanville
- COPD and Asthma Section, National Heart and Lung Institute, Imperial College London
- Jason L. Girkin
- Faculty of Health and Medicine and Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle
- Yee Man Ching
- COPD and Asthma Section, National Heart and Lung Institute, Imperial College London
- Andrea Marcellini
- COPD and Asthma Section, National Heart and Lung Institute, Imperial College London
- James D. Porter
- COPD and Asthma Section, National Heart and Lung Institute, Imperial College London
- Marie Toussaint
- COPD and Asthma Section, National Heart and Lung Institute, Imperial College London
- Ross P. Walton
- COPD and Asthma Section, National Heart and Lung Institute, Imperial College London
- Lydia J. Finney
- COPD and Asthma Section, National Heart and Lung Institute, Imperial College London
- Julia Aniscenko
- COPD and Asthma Section, National Heart and Lung Institute, Imperial College London
- Jie Zhu
- COPD and Asthma Section, National Heart and Lung Institute, Imperial College London
- Maria-Belen Trujillo-Torralbo
- COPD and Asthma Section, National Heart and Lung Institute, Imperial College London
- Maria Adelaide Calderazzo
- COPD and Asthma Section, National Heart and Lung Institute, Imperial College London
- Chris Grainge
- Faculty of Health and Medicine and Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle
- Su-Ling Loo
- Faculty of Health and Medicine and Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle
- Punnam Chander Veerati
- Faculty of Health and Medicine and Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle
- Prabuddha S. Pathinayake
- Faculty of Health and Medicine and Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle
- Kristy S. Nichol
- Faculty of Health and Medicine and Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle
- Andrew T. Reid
- Faculty of Health and Medicine and Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle
- Phillip L. James
- Genomic Medicine, National Heart and Lung Institute, Imperial College London
- Roberto Solari
- COPD and Asthma Section, National Heart and Lung Institute, Imperial College London
- Peter A. B. Wark
- Faculty of Health and Medicine and Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle
- Darryl A. Knight
- Faculty of Health and Medicine and Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle
- Miriam F. Moffatt
- Genomic Medicine, National Heart and Lung Institute, Imperial College London
- William O. Cookson
- Genomic Medicine, National Heart and Lung Institute, Imperial College London
- Michael R. Edwards
- COPD and Asthma Section, National Heart and Lung Institute, Imperial College London
- Patrick Mallia
- COPD and Asthma Section, National Heart and Lung Institute, Imperial College London
- Nathan W. Bartlett
- COPD and Asthma Section, National Heart and Lung Institute, Imperial College London
- Sebastian L. Johnston
- COPD and Asthma Section, National Heart and Lung Institute, Imperial College London
- DOI
- https://doi.org/10.1038/s41467-018-04574-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
Corticosteroid therapy is frequently used for chronic obstructive pulmonary disease (COPD) but its use is associated with increased risk of pneumonia. Here the authors show that corticosteroid use impairs innate and adaptive immunity to rhinovirus infection, which is restored by exogenous IFNβ.
