Nature Communications (Mar 2023)
Small molecule-nanobody conjugate induced proximity controls intracellular processes and modulates endogenous unligandable targets
Abstract
Induced proximity can be used to control diverse cellular processes. Here, the authors develop nanobody-based proximity inducers called SNACIPs, which can be used to regulate either tagged or endogenous proteins, and demonstrate their use in blocking microtubule nucleation for tumour growth inhibition in vivo.